National Nutrition and Food Technology Research Institute, Faculty of Nutrition Science and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Physiology Research Center and Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Neurosci Biobehav Rev. 2017 Feb;73:39-47. doi: 10.1016/j.neubiorev.2016.11.022. Epub 2016 Nov 30.
Searching for effective therapeutic agents to prevent neurodegeneration is a challenging task due to the growing list of neurodegenerative disorders associated with a multitude of inter-related pathways. The induction and inhibition of several different signaling pathways has been shown to slow down and/or attenuate neurodegeneration and decline in cognition and locomotor function. Among these signaling pathways, a new class of enzymes known as sirtuins or silent information regulators of gene transcription has been shown to play important regulatory roles in the ageing process. SIRT1, a nuclear sirtuin, has received particular interest due to its role as a deacetylase for several metabolic and signaling proteins involved in stress response, apoptosis, mitochondrial function, self-renewal, and neuroprotection. A new strategy to treat neurodegenerative diseases is targeted therapy. In this paper, we reviewed up-to-date findings regarding the targeting of SIRT1 by polyphenolic compounds, as a new approach in the search for novel, safe and effective treatments for neurodegenerative diseases. .
由于与多种相互关联的途径相关的神经退行性疾病不断增加，寻找有效的治疗药物来预防神经退行性变是一项具有挑战性的任务。已经证明，诱导和抑制几种不同的信号通路可以减缓和/或减轻神经退行性变以及认知和运动功能下降。在这些信号通路中，已经证明被称为沉默信息调节因子或沉默信息调节因子的基因转录的新一类酶在衰老过程中发挥重要的调节作用。核 SIRT1 作为几种代谢和信号蛋白的去乙酰化酶，因其在应激反应、细胞凋亡、线粒体功能、自我更新和神经保护中发挥作用而受到特别关注。针对神经退行性疾病的一种新的治疗策略是靶向治疗。在本文中，我们综述了多酚化合物靶向 SIRT1 的最新研究进展，作为寻找新型、安全、有效的神经退行性疾病治疗方法的新方法。
