Wurthmann C, Hartung H P, Dengler W, Gerhardt P
Neurologische Klinik, Universität Düsseldorf.
Dtsch Med Wochenschr. 1989 Oct 6;114(40):1528-31. doi: 10.1055/s-2008-1066792.
A 17-year-old adolescent had a recurrent episode of somnolence and morbid hunger (Kleine-Levin syndrome) three years after a first attack, from which he had spontaneously recovered. He was treated with 50 mg daily of clomipramine for the somnolence accompanied by disturbance of attention and memory. Under this treatment he developed thymoleptic symptoms with polyphagia, logorrhea and hyperactivity. Placed on a trial dose of at first 600 mg, then 400 mg carbamazepine daily the abnormal findings disappeared within a few days, and there has been no recurrence after some months. It is postulated, based on the observations of this case, that the Kleine-Levin syndrome, presumably a functional hypothalamic disorder, is closely related to the endogenous psychoses.
一名17岁青少年在首次发作三年后再次出现嗜睡和病理性饥饿（克莱恩-莱文综合征），首次发作后他已自行康复。他因嗜睡伴注意力和记忆力障碍接受每日50毫克氯米帕明治疗。在此治疗下，他出现了精神抑制症状，伴有贪食、多语和多动。起初每日试用600毫克，然后400毫克卡马西平，几天后异常症状消失，几个月后未再复发。基于该病例的观察推测，克莱恩-莱文综合征可能是一种功能性下丘脑疾病，与内源性精神病密切相关。
