Hamada K, Suginami H, Matsuura S
Department of Obstetrics and Gynecoloy, School of Medicine, Ehime University, Japan.
Jikken Dobutsu. 1989 Jul;38(3):187-94. doi: 10.1538/expanim1978.38.3_187.
Adult 15 female Japanese monkeys showing regular menstrual cycles were subjected to the daily blood sampling for the measurement of estradiol (E2), progesterone (P) and biological LH in the mating season. Monkeys were maintained under controlled conditions in a standardized environment. Of the 35 cycles observed, 18 (51.4%) were estimated as anovulatory cycles and 17 (48.6%) were ovulatory cycles. The anovulatory cycles were classified into three types according to the peak level of E2 (Type I: E2 less than 50 pg/ml 3 cycles, Type II: E2 less than 170 pg/ml 7 cycles, Type III: E2 greater than 170 pg/ml 8 cycles). The ovulatory cycles were classified into two Types according to the peak level of P (Type IV: P less than 5.0 ng/ml 5 cycles, Tyep V: P greater than 5.0 ng/ml 12 cycles). The menstrual cycle was 27.5 +/- 7.8 days. The differences between mid cycle LH surge and P level in Type IV and in Type V were statistically significant. It was revealed that female Japanese monkeys kept under controlled condition in the mating season showed high incidence of various types of anovulatory cycles and that the ovulatory cycles with low P elevation in the mid luteal phase showed low LH and P secretions on the mid cycle date.
对15只处于规律月经周期的成年雌性日本猕猴，在交配季节进行每日采血，以测定雌二醇（E2）、孕酮（P）和生物促黄体生成素（LH）。猕猴在标准化环境的可控条件下饲养。在观察到的35个周期中，18个（51.4%）被估计为无排卵周期，17个（48.6%）为排卵周期。无排卵周期根据E2峰值水平分为三种类型（I型：E2低于50 pg/ml，3个周期；II型：E2低于170 pg/ml，7个周期；III型：E2高于170 pg/ml，8个周期）。排卵周期根据P峰值水平分为两种类型（IV型：P低于5.0 ng/ml，5个周期；V型：P高于5.0 ng/ml，12个周期）。月经周期为27.5±7.8天。IV型和V型在周期中期LH峰与P水平之间的差异具有统计学意义。结果显示，在交配季节处于可控条件下的雌性日本猕猴出现各种类型无排卵周期的发生率较高，并且在黄体中期P升高较低的排卵周期在周期中期日期显示LH和P分泌较低。
