Serebrovskaia I A, Baĭmanova Kh M, Eliseeva G M, Evgen'ev V A
Fiziol Zh (1978). 1989 Jul-Aug;35(4):100-2.
Experiments on 23 white rats and 10 guinea pigs have shown that preliminarily indomethacin-induced inhibition of prostaglandins synthesis prevented development of pulmonary oedema, evoked by heterologous serum in rats and by vagotomy in guinea pigs. Fourfold infusion of indomethacin in experiments on 29 rats decreased extracellular fraction activity of the pulmonary surfactant and exhausted its cellular reserve.
对23只白鼠和10只豚鼠进行的实验表明,预先用消炎痛抑制前列腺素合成可防止大鼠因异种血清以及豚鼠因迷走神经切断术诱发的肺水肿的发生。在对29只大鼠进行的实验中,四倍剂量注射消炎痛降低了肺表面活性物质的细胞外部分活性,并耗尽了其细胞储备。