Daughtrey W C, Wier P J, Traul K A, Biles R W, Egan G F
Exxon Biomedical Sciences, Inc., East Millstone, New Jersey 08875.
Fundam Appl Toxicol. 1989 Aug;13(2):303-9. doi: 10.1016/0272-0590(89)90266-2.
Octyl acetate (CAS RN 108419-32-5) was administered via oral gavage to pregnant Sprague-Dawley rats on Gestation Days 6 through 15 at dose levels of 0, 0.1, 0.5, and 1.0 g/kg. The dams were weighed and observed for clinical signs of toxicity during pregnancy, and food consumption was measured. On Gestation Day 20 the dams were sacrificed and the fetuses were examined for external, visceral, and skeletal malformations and variations. The mid- and high-dose levels resulted in maternal toxicity as evidenced by reductions in body weight gain and food consumption. There were no statistically significant effects on embryo-fetal lethality or fetal growth for any treatment group. The number of litters with at least one malformed fetus and the mean percentage of the litter malformed were significantly (p less than 0.05) elevated in the high-dose group only. The results of the present study demonstrate that octyl acetate produced some evidence of developmental toxicity at a dose (1.0 g/kg) that was maternally toxic. Developmental toxicity was not observed at the maternally toxic 0.5 g/kg dose level or the maternally nontoxic dose level (0.1 g/kg). Therefore, these data indicate that octyl acetate is not a selective developmental toxicant in the rat.
在妊娠第6至15天，通过口服灌胃法给怀孕的斯普拉格-道利大鼠施用乙酸辛酯（化学物质登记号：108-41-8），剂量水平分别为0、0.1、0.5和1.0克/千克。在孕期对母鼠称重并观察其毒性临床体征，同时测量食物摄入量。在妊娠第20天处死母鼠，检查胎儿的外部、内脏和骨骼畸形及变异情况。中高剂量组出现了母体毒性，表现为体重增加和食物摄入量减少。任何处理组对胚胎-胎儿致死率或胎儿生长均无统计学显著影响。仅高剂量组中至少有一只畸形胎儿的窝数和窝内畸形胎儿的平均百分比显著升高（p小于0.05）。本研究结果表明，乙酸辛酯在产生母体毒性的剂量（1.0克/千克）下有一些发育毒性证据。在产生母体毒性的0.5克/千克剂量水平或未产生母体毒性的剂量水平（0.1克/千克）下未观察到发育毒性。因此，这些数据表明乙酸辛酯在大鼠中不是一种选择性发育毒物。
