拉沙病毒的细胞进入揭示了病毒与宿主细胞相互作用的新方面。
Lassa Virus Cell Entry Reveals New Aspects of Virus-Host Cell Interaction.
作者信息
Torriani Giulia, Galan-Navarro Clara, Kunz Stefan
机构信息
Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
出版信息
J Virol. 2017 Jan 31;91(4). doi: 10.1128/JVI.01902-16. Print 2017 Feb 15.
Abstract
Viral entry represents the first step of every viral infection and is a determinant for the host range and disease potential of a virus. Here, we review the latest developments on cell entry of the highly pathogenic Old World arenavirus Lassa virus, providing novel insights into the complex virus-host cell interaction of this important human pathogen. We will cover new discoveries on the molecular mechanisms of receptor recognition, endocytosis, and the use of late endosomal entry factors.
摘要
病毒进入是每次病毒感染的第一步，也是决定病毒宿主范围和致病潜力的因素。在此，我们综述了高致病性旧大陆沙粒病毒拉沙病毒进入细胞的最新进展，为这种重要人类病原体复杂的病毒-宿主细胞相互作用提供了新见解。我们将介绍受体识别、内吞作用以及晚期内体进入因子利用的分子机制方面的新发现。
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