阿达木单抗与非动脉炎性前部缺血性视神经病变：一例报告
Adalimumab and Non-Arteritic Anterior Ischaemic Optic Neuropathy: A Case Report.
作者信息
Kinard Krista, Walsh Jessica A, Penmetsa Gopi K, Warner Judith E A
机构信息
Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah Salt Lake City, Utah USA.
Department of Internal Medicine (Rheumatology Division), University of Utah Salt Lake City, Utah USA.
出版信息
Neuroophthalmology. 2014 Sep 10;38(5):272-277. doi: 10.3109/01658107.2014.925940. eCollection 2014.
Sequential anterior ischaemic optic neuropathy was observed in a patient treated with a tumour necrosis factor α (TNF) inhibitor, adalimumab, for ankylosing spondylitis. He developed decreased visual acuity in the right eye after 17 months of treatment. Findings showed right optic disc oedema with haemorrhages and visual field defect. Adalimumab was discontinued and vision stabilised. After restarting adalimumab, he developed optic neuropathy in the left eye. Findings showed optic disc oedema, with haemorrhages and visual field changes in the left eye. Adalimumab may be associated with optic neuropathy; providers prescribing TNF inhibitors should be aware of optic neuropathy as a potential complication.
一名使用肿瘤坏死因子α（TNF）抑制剂阿达木单抗治疗强直性脊柱炎的患者出现了顺序性前部缺血性视神经病变。治疗17个月后，他右眼视力下降。检查发现右眼视盘水肿伴出血及视野缺损。停用阿达木单抗后视力稳定。重新使用阿达木单抗后，他左眼出现视神经病变。检查发现左眼视盘水肿，伴有出血及视野改变。阿达木单抗可能与视神经病变有关；开具TNF抑制剂的医生应意识到视神经病变是一种潜在并发症。
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