[F] - 氟化物的捕获与释放：由鏻硼烷辅助的共沸干燥无亲核芳香族放射性氟化反应
[F]-Fluoride capture and release: azeotropic drying free nucleophilic aromatic radiofluorination assisted by a phosphonium borane.
作者信息
Perrio Cécile, Schmitt Sébastien, Pla Daniel, Gabbaï François P, Chansaenpak Kantapat, Mestre-Voegtle Béatrice, Gras Emmanuel
机构信息
Normandie Univ, UNICAEN, CEA, CNRS, UMR6301-ISTCT, LDM-TEP, Cyceron, Boulevard Henri Becquerel, 14000 Caen, France.
LCC, CNRS, UPR8241, UFTMP, 205, route de Narbonne, BP 44099, 31077 Toulouse Cedex 4, France.
出版信息
Chem Commun (Camb). 2016 Dec 22;53(2):340-343. doi: 10.1039/c6cc05168e.
[F]-Fluoride ready for aromatic nucleophilic substitution was prepared according to a simple process including trapping of aqueous [F]-fluoride on a cartridge pre-loaded with the phosphonium borane [(PhMeP)CH(BMes)], then releasing by elution of TBACN in dry acetonitrile. Subsequent radiofluorination was successfully applied to a model reaction and to the radiosynthesis of [F]-setoperone.
用于芳香亲核取代反应的[F] - 氟化物是根据一个简单的过程制备的，该过程包括将水性[F] - 氟化物捕获在预先装载有硼烷鏻[(PhMeP)CH(BMes)]的柱上，然后通过在干燥乙腈中洗脱四丁基氯化铵（TBACN）来释放。随后，放射性氟化成功应用于模型反应和[F] - 司替戊醇的放射性合成。
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