Sellheyer K, Spitznas M
Fortschr Ophthalmol. 1989;86(4):392-8.
In human embryos and fetuses with a gestation age of 9.5 to 24 weeks, differentiation of the ciliary muscle was examined by both light and transmission electron microscopy, and the surface morphology of the ciliary body was analyzed by scanning electron microscopy. Smooth muscle cells develop from mesenchymal elements or early fibroblasts located at the anterior rim of the optic cup. Musclelike cells exhibiting dense bodies and myofilaments were first distinguished during week 12 and smooth muscle cells with an adultlike appearance become apparent during week 15/16. A cellular maturation process can be observed up to week 22. Fibroblasts separating the muscle cell layers from each other also derive from the same precursor cells, as do smooth muscle cells, thereby pointing out the close relationship between the two cell types. The first radial ciliary folds could be observed at week 10.3 by scanning electron microscopy. However, true ciliary processes have only been described at week 24. The ciliary processes observed during week 24 only differed from those of the adult eye by the dimensions and lack of surface infoldings. A primitive pars plana was first identified during week 24. The morphological basis for aqueous humor production is discussed.
在妊娠年龄为9.5至24周的人类胚胎和胎儿中，通过光学显微镜和透射电子显微镜检查睫状肌的分化情况，并通过扫描电子显微镜分析睫状体的表面形态。平滑肌细胞由位于视杯前缘的间充质成分或早期成纤维细胞发育而来。在第12周时首次区分出具有致密小体和肌丝的肌样细胞，在第15/16周时出现外观类似成人的平滑肌细胞。直到第22周都可观察到细胞成熟过程。将肌细胞层彼此分开的成纤维细胞也与平滑肌细胞一样，源自相同的前体细胞，从而表明这两种细胞类型之间的密切关系。通过扫描电子显微镜在第10.3周时可观察到最初的放射状睫状褶。然而，真正的睫状突仅在第24周时被描述。在第24周时观察到的睫状突与成年眼的睫状突仅在尺寸和缺乏表面褶皱方面有所不同。在第24周时首次识别出原始的睫状体扁平部。本文讨论了房水生成的形态学基础。
