Zhu Lixia, Lui Kung-Jong
a Department of Mathematics and Statistics, College of Sciences , San Diego State University , San Diego , California , USA.
J Biopharm Stat. 2017;27(5):834-844. doi: 10.1080/10543406.2016.1269785. Epub 2017 Feb 6.
Three test procedures accounting for patients with tied responses based on Prescott's ideas are developed for comparing three treatments under a three-period crossover trial in binary data. Monte Carlo simulation is employed to evaluate the performance of these test procedures in a variety of situations. The test procedures proposed here are noted to have power larger than those procedures, which utilize only those patients with un-tied responses. The data taken from a three-period crossover trial comparing two different doses of an analgesic with placebo for the relief of primary dysmenorrhea are used to illustrate the use of the test procedures developed here.
基于普雷斯科特的想法，开发了三种针对具有关联反应患者的检验程序，用于在三期交叉试验的二元数据中比较三种治疗方法。采用蒙特卡罗模拟来评估这些检验程序在各种情况下的性能。这里提出的检验程序的功效被指出比那些仅使用无关联反应患者的程序更大。从一项三期交叉试验中获取的数据用于说明此处开发的检验程序的用法，该试验比较了两种不同剂量的镇痛药与安慰剂对原发性痛经的缓解效果。
