Saunders Gretchen R B, McGue Matt, Iacono William G, Elkins Irene J
Department of Psychology, University of Minnesota, Minneapolis, Minnesota.
J Stud Alcohol Drugs. 2017 Jan;78(1):49-58. doi: 10.15288/jsad.2017.78.49.
The purpose of the current study was to evaluate parent-offspring resemblance for alcohol consumption and dependence symptoms, including sex-specific effects, and how these patterns change across adolescence and early adulthood.
Three cohorts of twins were assessed longitudinally at five time points between ages 14 and 29 years, with parents directly assessed at intake, using structured interviews. Twin offspring and parents from the population-based Minnesota Twin Family Study were included for a total sample size of 3,762 offspring (52% female) and their parents. Alcohol use was measured using an index based on drinking quantity, frequency, maximum drinks, and number of intoxications. Alcohol dependence symptom counts were also used.
Parent-offspring correlations for alcohol consumption increased from age 14 (r = .12) to age 17 (r = .25), remained stable from ages 17 through 24, and then decreased slightly by age 29 (r = .19). Familial resemblance for symptoms of alcohol dependence peaked at age 17 (r = .18) then decreased through age 29 (r = .11). Parent-offspring correlations of both measures did not vary significantly by sex of offspring or sex of parent.
Overall, parent-offspring resemblance for alcohol use and problems is relatively stable after early adulthood, with resemblance for alcohol use at higher magnitudes across offspring development. Evidence for differential resemblance based on sex of offspring or parents was lacking.
本研究旨在评估酒精消费与依赖症状的亲子相似性,包括性别特异性影响,以及这些模式在青春期和成年早期如何变化。
对三组双胞胎在14岁至29岁之间的五个时间点进行纵向评估,父母在入组时通过结构化访谈直接进行评估。纳入了基于人群的明尼苏达双胞胎家庭研究中的双胞胎后代及其父母,总样本量为3762名后代(52%为女性)及其父母。使用基于饮酒量、频率、最大饮酒量和醉酒次数的指数来衡量酒精使用情况。还使用了酒精依赖症状计数。
酒精消费的亲子相关性从14岁时的r = 0.12增加到17岁时的r = 0.25,在17岁至24岁之间保持稳定,然后到29岁时略有下降(r = 0.19)。酒精依赖症状的家族相似性在17岁时达到峰值(r = 0.18),然后到29岁时下降(r = 0.11)。这两种测量方法的亲子相关性在后代性别或父母性别上没有显著差异。
总体而言,成年早期后酒精使用和问题的亲子相似性相对稳定,在后代发育过程中酒精使用的相似性程度更高。缺乏基于后代或父母性别的差异相似性证据。