Michels Karin B, Cohn Barbara A, Goldberg Mandy, Flom Julie D, Dougan Marcelle, Terry Mary Beth
Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts;
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts.
Pediatrics. 2016 Nov;138(Suppl 1):S34-S41. doi: 10.1542/peds.2015-4268F.
We examined the relation between maternal anthropometry and mammographic density in the adult daughter using prospectively collected data.
Our study included a total of 700 mother-daughter dyads participating in an adult follow-up of women born in 2 US birth cohorts: the Child Health and Development Study and the Boston, Massachusetts, and Providence, Rhode Island sites of the National Collaborative Perinatal Project.
We observed an increased percent breast density at a mean age of 43.1 years in the daughters of mothers who gained 5 kg or less during pregnancy compared with mother-daughter pairs in which the mother gained 5 to 10 kg (β = 4.8, 95% confidence interval: 1.0 to 8.6). The daughters of mothers who were overweight at the time of conception (prepregnancy BMI ≥25) and who gained >5 kg during pregnancy had a lower percent density (β = -3.2, 95% confidence interval: -6.2 to -0.2) compared with mothers with a BMI <25 at conception who gained >5 kg.
We did not find any strong and consistent patterns between maternal anthropometry and the daughter's breast density, a strong predictor of breast cancer risk. A modest association between low gestational weight gain and increased breast density 40 years later in the daughter was observed, even after accounting for adult body size, and if confirmed, possible mechanisms need to be further elucidated.
我们使用前瞻性收集的数据研究了成年女儿的母亲人体测量学指标与乳房X线密度之间的关系。
我们的研究共纳入了700对母女，她们参与了对出生于美国两个出生队列的女性的成人随访研究：儿童健康与发展研究以及国家围产期协作项目在马萨诸塞州波士顿和罗德岛州普罗维登斯的研究点。
我们观察到，与孕期体重增加5至10千克的母女对相比，孕期体重增加5千克或更少的母亲的女儿在平均43.1岁时乳房密度百分比增加（β = 4.8，95%置信区间：1.0至8.6）。与受孕时BMI<25且孕期体重增加>5千克的母亲相比，受孕时超重（孕前BMI≥25）且孕期体重增加>5千克的母亲的女儿密度百分比更低（β = -3.2，95%置信区间：-6.2至-0.2）。
我们未发现母亲人体测量学指标与女儿乳房密度之间存在任何强烈且一致的模式，而乳房密度是乳腺癌风险的一个重要预测指标。即使在考虑了成年后的体型之后，我们仍观察到孕期体重增加少与40年后女儿乳房密度增加之间存在适度关联，若该关联得到证实，则需要进一步阐明可能的机制。
