Nwokediuko Sylvester Chuks, Ibegbulam Obike Godswill
Department of Medicine, University of Nigeria Teaching Hospital Ituku/Ozalla, Enugu, Nigeria.
Department of Hematology, University of Nigeria Teaching Hospital Ituku/Ozalla, Enugu, Nigeria.
Gastroenterology Res. 2010 Aug;3(4):167-170. doi: 10.4021/gr226e. Epub 2010 Jul 20.
Bleeding time has been used for a long time as a global test of platelet function. Due to a number of pitfalls the test has been losing popularity. This study was designed to determine the prevalence of prolonged bleeding time in Nigerians with chronic liver disease in relation to other indices of hemostasis.
Bleeding time, platelet count, prothrombin time (PT) and activated partial thromboplastin time (aPTT) were determined in patients with chronic liver disease seen over a twenty-eight-month period. Liver disease severity was graded using Child's score.
Only 14 of 164 (8.5%) patients with chronic liver disease had prolonged bleeding time while 60 patients (36.6%) had significantly prolonged PT. Thirty seven patients (22.6%) had prolonged aPTT. Bleeding time showed positive correlation with PT and aPTT but negative correlation with platelet count.
Bleeding time is not sensitive in detecting disorders of hemostasis in patients with chronic liver disease although it correlates significantly with other indices of hemostasis.
出血时间长期以来一直作为血小板功能的一项综合检测指标。由于存在诸多缺陷，该检测方法的应用越来越少。本研究旨在确定尼日利亚慢性肝病患者中出血时间延长的发生率，并与其他止血指标进行比较。
对在28个月期间就诊的慢性肝病患者测定出血时间、血小板计数、凝血酶原时间（PT）和活化部分凝血活酶时间（aPTT）。采用Child评分法对肝病严重程度进行分级。
164例慢性肝病患者中仅有14例（8.5%）出血时间延长，而60例患者（36.6%）PT显著延长。37例患者（22.6%）aPTT延长。出血时间与PT和aPTT呈正相关，但与血小板计数呈负相关。
出血时间在检测慢性肝病患者的止血障碍方面并不敏感，尽管它与其他止血指标显著相关。
