Koczerginski D, Kennedy S H, Swinson R P
Toronto General Hospital, University of Toronto, Canada.
Int Clin Psychopharmacol. 1989 Jul;4(3):195-9. doi: 10.1097/00004850-198907000-00002.
Clonazepam, a benzodiazepine with anticonvulsant properties, has recently been found to be effective in the control of acute mania. Its use in combination with lithium has been advocated. Here 5 cases are presented in which the combination of clonazepam (2 mg-16 mg) plus lithium (900 mg-2400 mg) produced a neurotoxic syndrome with ataxia and dysarthria. In all cases the syndrome was reversible.
