Paquet C, Gaillard J M, Tissot R
Acta Psychiatr Belg. 1978 Mar-Apr;78(2):374-82.
This work is based on the observation of memory troubles before sleep in patients with sleep problems treated with flunitrazepam. Eight subjects are tested in two sessions, flunitrazepam and placebo, in double blind, with memory tests given the evening after medication and controlled the next morning. One additional test is controlling vigilance. The results show that memory is significantly disturbed by flunitrazepam, both for direct and delayed memory, the next day. On the contrary, recognition is not altered, neither vigilance.
这项研究基于对使用氟硝西泮治疗睡眠问题的患者睡前记忆障碍的观察。八名受试者分两个阶段进行测试，采用双盲法，分别给予氟硝西泮和安慰剂，服药当晚进行记忆测试，并于次日上午进行对照。另外还进行一项警觉性测试。结果表明，氟硝西泮会显著干扰次日的即时记忆和延迟记忆。相反，识别能力未受影响，警觉性也未改变。
