Wittmann F W, Ring P A
East Surrey Hospital, Redhill, England.
J Arthroplasty. 1989 Sep;4(3):253-6. doi: 10.1016/s0883-5403(89)80021-x.
Blood loss associated with uncemented total hip arthroplasty can be considerable, and any simple and safe means of reducing this loss and hence the volume of blood transfused during surgery would be valuable. The authors conducted a randomized trial using Colgen, a nondenatured collagen with hemostatic properties, in 76 patients undergoing uncemented total hip arthroplasty. Thirty-eight patients had Colgen sprinkled around the reduced hip joint after arthroplasty and 38 patients acted as controls. Analysis, using Student's t-test, showed no difference between the groups in measured blood loss at operation. However, after surgery in the Colgen group both visible measured blood loss (P less than .05) and total calculated blood loss (P less than .01) were significantly reduced. These results are particularly relevant today, when blood transfusion itself is a potential danger and should be kept to the necessary minimum.
非骨水泥型全髋关节置换术相关的失血可能相当可观，因此，任何能减少这种失血从而减少手术中输血量的简单且安全的方法都将很有价值。作者对76例接受非骨水泥型全髋关节置换术的患者进行了一项随机试验，使用具有止血特性的非变性胶原蛋白Colgen。38例患者在关节置换术后将Colgen撒在复位后的髋关节周围，38例患者作为对照。使用学生t检验进行分析，结果显示两组在术中测量的失血量方面没有差异。然而，在Colgen组手术后，可见的测量失血量（P小于0.05）和计算出的总失血量（P小于0.01）均显著减少。在如今输血本身就是一种潜在危险且应尽量减少到必要最低限度的情况下，这些结果尤为重要。
