鞘内注射巴氯芬与Hoffmann反射（H反射）
Intrathecal baclofen and the H-reflex.
作者信息
Macdonell R A, Talalla A, Swash M, Grundy D
机构信息
Department of Neurology, London Hospital, United Kingdom.
出版信息
J Neurol Neurosurg Psychiatry. 1989 Sep;52(9):1110-2. doi: 10.1136/jnnp.52.9.1110.
Abstract
Baclofen was given intrathecally to six patients with severe lower limb spasticity due to traumatic spinal cord injury. The effects of the drug on spasticity and the ratio between the maximum amplitude of the H reflex and the M response from the soleus (Hmax/Mmax ratio) were assessed. In each patient, spasticity was reduced following intrathecal baclofen and in four patients there was a reduction in the amplitude of the H reflex and Hmax/Mmax ratio. These results suggest that the Hmax/Mmax ratio may be helpful in establishing optimum drug dosage, particularly when the drug is used on a chronic basis.
摘要
对6名因创伤性脊髓损伤导致严重下肢痉挛的患者进行鞘内注射巴氯芬。评估了该药物对痉挛以及比目鱼肌H反射最大波幅与M反应之间的比率（Hmax/Mmax比率）的影响。在每位患者中，鞘内注射巴氯芬后痉挛减轻，4名患者的H反射波幅和Hmax/Mmax比率降低。这些结果表明，Hmax/Mmax比率可能有助于确定最佳药物剂量，尤其是在长期使用该药物时。
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