Xue Jie, Huang Wensi, Chen Xiaoli, Li Qian, Cai Zhengyi, Yu Tieer, Shao Bei
Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
J Stroke Cerebrovasc Dis. 2017 Mar;26(3):650-657. doi: 10.1016/j.jstrokecerebrovasdis.2016.11.010. Epub 2016 Dec 9.
Neutrophil-to-lymphocyte ratio is an independent predictor of mortality in patients with acute ischemic stroke. However, it is uncertain whether neutrophil-to-lymphocyte ratio is related with functional outcome and recurrent ischemic stroke. In this study, we aimed to investigate the relationship of neutrophil-to-lymphocyte ratio with stroke severity, functional outcome, and recurrent ischemic stroke after acute ischemic stroke.
A total of 280 patients with acute ischemic stroke were included in the study. Patients were divided into 3 groups according to the neutrophil-to-lymphocyte ratio value (<2, 2-3, >3). Demographic, clinical, and laboratory data were collected for all patients. We evaluated the association between neutrophil-to-lymphocyte ratio and (1) stroke severity on admission, (2) functional outcome at 3 months, and (3) recurrent ischemic stroke. Regression analyses were performed, adjusting for confounders.
After adjustment for potential confounders, neutrophil-to-lymphocyte ratio was associated with an increased risk of stroke severity on admission (odds ratio [OR] 1.364, 95% confidence interval [CI] 1.101-1.690, P = .005) and primary unfavorable outcome (OR 1.455, 95% CI 1.083-1.956, P = .013). After a median of 1.13 years (interquartile range.91-1.42) of follow-up, neutrophil-to-lymphocyte ratio was associated with recurrent ischemic stroke after adjustment (hazard ratio 1.499, 95% CI 1.161-1.935, P = .002).
Our study suggests that neutrophil-to-lymphocyte ratio is associated with stroke severity on admission, primary unfavorable functional outcome, and recurrent ischemic stroke in patients with acute ischemic stroke.
中性粒细胞与淋巴细胞比值是急性缺血性脑卒中患者死亡率的独立预测指标。然而，中性粒细胞与淋巴细胞比值是否与功能预后及复发性缺血性脑卒中相关尚不确定。在本研究中，我们旨在探讨急性缺血性脑卒中后中性粒细胞与淋巴细胞比值与卒中严重程度、功能预后及复发性缺血性脑卒中之间的关系。
本研究共纳入280例急性缺血性脑卒中患者。根据中性粒细胞与淋巴细胞比值（<2、2 - 3、>3）将患者分为3组。收集所有患者的人口统计学、临床和实验室数据。我们评估了中性粒细胞与淋巴细胞比值与（1）入院时的卒中严重程度、（2）3个月时的功能预后以及（3）复发性缺血性脑卒中之间的关联。进行了回归分析，并对混杂因素进行了校正。
在对潜在混杂因素进行校正后，中性粒细胞与淋巴细胞比值与入院时卒中严重程度增加的风险相关（比值比[OR] 1.364，95%置信区间[CI] 1.101 - 1.690，P = 0.005）以及主要不良预后相关（OR 1.455，95% CI 1.083 - 1.956，P = 0.013）。经过中位1.13年（四分位间距0.91 - 1.42）的随访，校正后中性粒细胞与淋巴细胞比值与复发性缺血性脑卒中相关（风险比1.499，95% CI 1.161 - 1.935，P = 0.002）。
我们的研究表明，中性粒细胞与淋巴细胞比值与急性缺血性脑卒中患者入院时的卒中严重程度、主要不良功能预后及复发性缺血性脑卒中相关。
