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Synthesis and investigation of effects of 2-[4- [[(arylamino)carbonyl]amino]phenoxy]-2-methylpropionic acids on the affinity of hemoglobin for oxygen: structure-activity relationships.

作者信息

Lalezari I, Lalezari P

机构信息

Organic Chemistry Laboratory, Montefiore Medical Center, Bronx, New York.

出版信息

J Med Chem. 1989 Oct;32(10):2352-7. doi: 10.1021/jm00130a021.

DOI:10.1021/jm00130a021
PMID:2795607
Abstract

A series of 2-[4-[[[(substituted-phenyl)amino]carbonyl]amino]phenoxy]-2- methylpropionic acids and other substituted phenoxyacetic acids were synthesized and tested for their ability to reduce the affinity of hemoglobin for oxygen. 2-[4-[[[(3,4,5-trichlorophenyl)amino]carbonyl]amino]phenoxy]-2- methylpropionic acid was found to be the most potent compound known. Structure-activity relationships of the compounds synthesized are discussed.

摘要

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