1 Centro de Lasers e Aplicações, IPEN/CNEN, São Paulo, SP, Brazil.
2 Instituto de Física, Universidade de São Paulo, São Paulo, SP, Brazil.
Appl Spectrosc. 2017 Jul;71(7):1560-1567. doi: 10.1177/0003702816683685. Epub 2016 Dec 20.
Standard lipoprotein measurements of triglycerides, total cholesterol, low-density lipoproteins (LDL), and high-density lipoproteins (HDL) fail to identify many lipoprotein abnormalities that contribute to cardiovascular heart diseases (CHD). Studies suggested that the presence of CHD is more strongly associated with the HDL subspecies than with total HDL cholesterol levels. The HDL particles can be collected in at least three subfractions, the HDL2b, HDL2a, and HDL3. More specifically, atherosclerosis is associated with low levels of HDL2. In this work, the optical spectroscopic properties of europium tetracycline (EuTc) complex in the presence of different HDL subspecies was studied. The results show that the europium spectroscopic properties in the EuTc complex are influenced by sizes and concentrations of subclasses. Eu emission intensity and lifetime can discriminate the subfractions HDL3 and HDL2b.
标准脂蛋白测量法，如甘油三酯、总胆固醇、低密度脂蛋白（LDL）和高密度脂蛋白（HDL），无法识别出许多导致心血管疾病（CHD）的脂蛋白异常。研究表明，HDL 亚种的存在与 CHD 的关联性比总 HDL 胆固醇水平更强。HDL 颗粒至少可以分为三个亚组分，即 HDL2b、HDL2a 和 HDL3。更具体地说，动脉粥样硬化与 HDL2 水平低有关。在这项工作中，研究了铕四环素（EuTc）配合物在不同 HDL 亚组分存在下的光学光谱特性。结果表明，EuTc 配合物中 Eu 的光谱性质受亚类的大小和浓度的影响。Eu 的发射强度和寿命可以区分 HDL3 和 HDL2b 亚组分。
