Nwokediuko Sylvester Chuks, Uchenna Ijoma, Esther Ofoegbu, Okechukwu Okafor, Augustine Onuh, Charity Ajuyah
Departments of Medicine, University of Nigeria Teaching Hospital Ituku/Ozall, Enugu, Nigeria.
Departments of Morbid Anatomy, University of Nigeria Teaching Hospital Ituku/Ozall, Enugu, Nigeria.
Gastroenterology Res. 2010 Feb;3(1):46-49. doi: 10.4021/gr2010.02.171w. Epub 2010 Jan 20.
Hepatocelluar carcinoma is one of the commonest cancers in Nigeria. Some patients may manifest a variety of paraneoplastic syndromes. Carcinoid syndrome is an extremely rare presentation of hepatocellular carcinoma. A 57-year old man presented with recurrent facial flushing and diarrhea, tricuspid regurgitation, and very high level of urinary hydroxyindoleacetic acid (HIAA) as the first manifestation of a multicentric hepatic lesion which proved histologically to be hepatocellular carcinoma. The lesions also exhibited arterial hypervascularization on contrast enhanced computerized tomography. The patient is still alive after 6 years of symptoms.
肝细胞癌是尼日利亚最常见的癌症之一。一些患者可能会出现各种副肿瘤综合征。类癌综合征是肝细胞癌极为罕见的表现形式。一名57岁男性以反复面部潮红、腹泻、三尖瓣反流以及尿中高香草酸(HIAA)水平极高为首发症状,这些症状是多中心肝脏病变的表现,经组织学证实为肝细胞癌。在增强计算机断层扫描中,这些病变还表现出动脉期血管强化。该患者出现症状6年后仍然存活。