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肾上腺皮质癌患者的非胰岛细胞瘤性低血糖症

Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma.

作者信息

Kim Se Won, Lee Seung-Eun, Oh Young Lyun, Kim Seokhwi, Park Sun Hee, Kim Jae Hyeon

机构信息

Division of Endocrinology, Department of Internal Medicine, Sahmyook Medical Center, Seoul, Republic of Korea.

Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

出版信息

Case Rep Endocrinol. 2016;2016:5731417. doi: 10.1155/2016/5731417. Epub 2016 Nov 10.

DOI:10.1155/2016/5731417
PMID:27957352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5121447/
Abstract

Nonislet cell tumor hypoglycemia (NICTH) is a rare but serious paraneoplastic syndrome in which a tumor secretes incompletely processed precursors of insulin-like growth factor-II (IGF-II), causing hypoglycemia. Here, we report an exceptional case of NICTH caused by nonfunctioning adrenocortical carcinoma in a 39-year-old male with recurrent hypoglycemia. The patient's serum IGF-II/IGF-I ratio had increased to 27.8. The serum level of the IGF-II/IGF-I ratio was normalized after removal of the tumor, and the hypoglycemic attacks no longer occurred after the operation.

摘要

非胰岛细胞瘤性低血糖症（NICTH）是一种罕见但严重的副肿瘤综合征，肿瘤分泌未完全加工的胰岛素样生长因子-II（IGF-II）前体，导致低血糖。在此，我们报告一例由无功能肾上腺皮质癌引起的NICTH罕见病例，患者为一名39岁男性，反复出现低血糖。患者血清IGF-II/IGF-I比值升至27.8。切除肿瘤后，血清IGF-II/IGF-I比值恢复正常，术后低血糖发作不再出现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa5f/5121447/05491a6c026e/CRIE2016-5731417.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa5f/5121447/41e79ce710c7/CRIE2016-5731417.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa5f/5121447/05491a6c026e/CRIE2016-5731417.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa5f/5121447/41e79ce710c7/CRIE2016-5731417.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa5f/5121447/05491a6c026e/CRIE2016-5731417.002.jpg

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本文引用的文献

1
Management of non-islet-cell tumor hypoglycemia: a clinical review.非胰岛细胞瘤性低血糖症的管理：临床综述。
J Clin Endocrinol Metab. 2014 Mar;99(3):713-22. doi: 10.1210/jc.2013-3382. Epub 2013 Dec 11.
2
Update in adrenocortical carcinoma.肾上腺皮质癌的最新进展。
J Clin Endocrinol Metab. 2013 Dec;98(12):4551-64. doi: 10.1210/jc.2013-3020. Epub 2013 Sep 30.
3
[Adrenal carcinoma induced hypoglycemia].
Medicina (B Aires). 2013;73(4):339-42.
一名晚期肝细胞癌患者的复发性低血糖症
J Community Hosp Intern Med Perspect. 2024 Nov 2;14(6):94-96. doi: 10.55729/2000-9666.1406. eCollection 2024.
4
Severe Cholestatic Jaundice (Stauffer Syndrome) as a Rare Paraneoplastic Manifestation in Adrenocortical Carcinoma.严重胆汁淤积性黄疸（斯托弗综合征）作为肾上腺皮质癌罕见的副肿瘤表现
J Endocr Soc. 2022 Jun 29;6(8):bvac101. doi: 10.1210/jendso/bvac101. eCollection 2022 Aug 1.
5
An Adrenocortical Carcinoma Associated with Non-Islet Cell Tumor Hypoglycemia and Aberrant ACTH Production.一例与非胰岛细胞瘤性低血糖症及异常促肾上腺皮质激素分泌相关的肾上腺皮质癌
Case Rep Endocrinol. 2020 Mar 9;2020:2025631. doi: 10.1155/2020/2025631. eCollection 2020.
6
[Metabolic disorders as paraneoplastic syndromes].[作为副肿瘤综合征的代谢紊乱]
Internist (Berl). 2018 Feb;59(2):114-124. doi: 10.1007/s00108-017-0357-2.
4
Cushing's syndrome and big IGF-II associated hypoglycaemia in a patient with adrenocortical carcinoma.一名肾上腺皮质癌患者的库欣综合征与大IGF-II相关低血糖症
BMJ Case Rep. 2010;2010. doi: 10.1136/bcr.07.2009.2100. Epub 2010 Mar 30.
5
IGF2-induced hypoglycemia unresponsive to everolimus.胰岛素样生长因子2诱导的低血糖对依维莫司无反应。
QJM. 2014 Apr;107(4):297-300. doi: 10.1093/qjmed/hcr249. Epub 2011 Dec 14.
6
Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II.了解 IGF-II 对胰岛素和胰岛素样生长因子 (IGF) 受体激活的作用机制。
PLoS One. 2011;6(11):e27488. doi: 10.1371/journal.pone.0027488. Epub 2011 Nov 28.
7
The Weiss system for evaluating adrenocortical neoplasms: 25 years later.25年后的魏斯肾上腺皮质肿瘤评估系统。
Hum Pathol. 2009 Jun;40(6):757-68. doi: 10.1016/j.humpath.2009.03.010.
8
Non-islet cell tumor hypoglycemia.非胰岛细胞瘤性低血糖症
J Pain Symptom Manage. 2009 Apr;37(4):e1-3. doi: 10.1016/j.jpainsymman.2008.11.004.
9
Non-islet cell tumour-induced hypoglycaemia: a review of the literature including two new cases.非胰岛细胞瘤所致低血糖症：文献综述并附两例新病例
Endocr Relat Cancer. 2007 Dec;14(4):979-93. doi: 10.1677/ERC-07-0161.
10
Hypoglycemia associated with the production of insulin-like growth factor II in adrenocortical carcinoma.肾上腺皮质癌中与胰岛素样生长因子II产生相关的低血糖症。
Intern Med. 2001 Aug;40(8):759-63. doi: 10.2169/internalmedicine.40.759.