Kobayashi M, Yumiba C, Kawaguchi Y, Tanaka Y, Ueda K, Komazawa Y, Kaneda M, Tanihiro M, Okada K
Rinsho Ketsueki. 1989 May;30(5):663-7.
Antineutrophil antibodies in the sera against peripheral blood neutrophils were examined in 8 infants (2 to 12 months of age) with neutropenia (absolute neutrophil count 0 to 480/microliter). The antibodies were detected by granulocyte indirect immunofluorescence test (GIIFT) and microleukocyte agglutination test (M-LAT). Three of the 6 serum samples with chronic benign-type neutropenia reacted in both GIIFT and M-LAT. In 2 of these 3 samples, the antibody was proved to be specific to neutrophil antigen NA1 by the absorption experiment. Neither the GIIFT nor the M-LAT showed the antibody in two patients with Kostmann-type neutropenia. These results suggest that the examination of antibodies against neutrophils is essential to the evaluation of the patients with chronic benign-type neutropenia in infancy.
对8名（2至12个月大）患有中性粒细胞减少症（绝对中性粒细胞计数为0至480/微升）的婴儿血清中针对外周血中性粒细胞的抗中性粒细胞抗体进行了检测。通过粒细胞间接免疫荧光试验（GIIFT）和微白细胞凝集试验（M-LAT）检测抗体。6例慢性良性型中性粒细胞减少症患者的血清样本中有3例在GIIFT和M-LAT中均呈阳性反应。在这3个样本中的2个中，通过吸收试验证明抗体对中性粒细胞抗原NA1具有特异性。在2例 Kostmann型中性粒细胞减少症患者中，GIIFT和M-LAT均未显示出抗体。这些结果表明，检测抗中性粒细胞抗体对于评估婴儿慢性良性型中性粒细胞减少症患者至关重要。
