Jaffe Elaine S
Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; email:
Annu Rev Pathol. 2017 Jan 24;12:1-24. doi: 10.1146/annurev-pathol-052016-100351. Epub 2016 Dec 5.
This review reflects the trajectory of my career in hematopathology, and my personal reflections on scientific advances in the field. During the course of more than 40 years, the approach to classification of hematological malignancies has evolved from descriptive approaches, based on either cytological or clinical features, to a modern approach, which incorporates cutting-edge technologies. My philosophy has focused on defining individual diseases, an approach that can best lead to an understanding of molecular pathogenesis. To quote Carolus Linnaeus ( 1 , p. 19), the father of taxonomy, "The first step in wisdom is to know the things themselves; this notion consists in having a true idea of the objects; objects are distinguished and known by classifying them methodically and giving them appropriate names. Therefore, classification and name-giving will be the foundation of our science."
这篇综述反映了我在血液病理学领域的职业生涯轨迹，以及我对该领域科学进展的个人思考。在40多年的时间里，血液系统恶性肿瘤的分类方法已从基于细胞学或临床特征的描述性方法，演变为结合前沿技术的现代方法。我的理念一直专注于定义个体疾病，这种方法最有助于理解分子发病机制。引用分类学之父卡罗勒斯·林奈（1，第19页）的话来说：“智慧的第一步是了解事物本身；这个概念在于对对象有一个真实的概念；通过系统地对对象进行分类并给它们赋予适当的名称来区分和认识对象。因此，分类和命名将是我们科学的基础。”
