癌症中的细胞外囊泡：转移的细胞间介质
Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis.
作者信息
Becker Annette, Thakur Basant Kumar, Weiss Joshua Mitchell, Kim Han Sang, Peinado Hector, Lyden David
机构信息
Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10021, USA.
Pediatric Clinic III, University Clinic of Essen, Hufelandstrasse-55, Essen 45147, Germany.
出版信息
Cancer Cell. 2016 Dec 12;30(6):836-848. doi: 10.1016/j.ccell.2016.10.009.
Abstract
Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. Accordingly, EVs play an essential role in both primary tumor growth and metastatic evolution. EVs orchestrate multiple systemic pathophysiological processes, such as coagulation, vascular leakiness, and reprogramming of stromal recipient cells to support pre-metastatic niche formation and subsequent metastasis. Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development.
摘要
肿瘤分泌的细胞外囊泡（EVs）是肿瘤细胞与局部和远处微环境中基质细胞之间细胞间通讯的关键介质。因此，EVs在原发性肿瘤生长和转移演变中都起着至关重要的作用。EVs协调多种全身病理生理过程，如凝血、血管渗漏以及基质受体细胞的重编程，以支持前转移微环境的形成和随后的转移。临床上，EVs可能是癌症进展的生物标志物和新型治疗靶点，特别是用于预测和预防未来的转移发展。
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