Li Jingjing, Chen Xiang-Ya, Soo Yannie, Leung Thomas W, Zeng Jinsheng, Wong Ka-Sing
Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Eur Neurol. 2017;77(1-2):80-86. doi: 10.1159/000454678. Epub 2016 Dec 14.
CT perfusion (CTP) imaging provides quantitative evaluation of cerebral perfusion flow and volume. Our previous findings showed that benign oligemia caused by intracranial large artery disease may be existent in subacute stroke.
We aimed at comparing the topographic patterns and clinical outcome of stroke patients with and without persistent benign oligemia as defined by CTP imaging.
Consecutive ischemic stroke patients who were referred for CTP in 2009 were screened. The topographic patterns (cortical, borderzone or perforating artery territory infarcts) were assessed by diffusion-weighted imaging (DWI). The clinical outcome was defined by modified Rankin score at 6 months after stroke onset.
Totally, 26 stroke patients were recruited. Benign oligemia in subacute stage was detected in 15 patients. The occurrence of borderzone infarction was higher in stroke patients with benign oligemia than those without (p = 0.036).
The topographic pattern of DWI may be different between the intracranial arterial disease patients with and without benign oligemia on CTP in subacute stroke.
CT灌注（CTP）成像可对脑灌注流量和容积进行定量评估。我们之前的研究结果表明，颅内大动脉疾病所致的良性低灌注可能存在于亚急性卒中患者中。
我们旨在比较经CTP成像定义的存在和不存在持续性良性低灌注的卒中患者的梗死灶分布模式和临床结局。
对2009年因CTP检查而转诊的连续性缺血性卒中患者进行筛查。通过弥散加权成像（DWI）评估梗死灶分布模式（皮质、边缘带或穿支动脉供血区梗死）。临床结局采用卒中发病后6个月的改良Rankin量表评分进行定义。
共纳入26例卒中患者。15例患者在亚急性期检测到良性低灌注。存在良性低灌注的卒中患者边缘带梗死的发生率高于无良性低灌注者（p = 0.036）。
亚急性卒中患者中，颅内动脉疾病患者在CTP上存在和不存在良性低灌注时，DWI的梗死灶分布模式可能不同。
