Gonchar' M G, Vavrik Zh M, Genyk S N
Klin Khir (1962). 1989(7):35-7.
In the experiment on dogs, the authors modelled acute ischemia of the extremities and studied the activity of lactate dehydrogenase in the blood serum. In circulatory ischemia for 2 and 4 h, the metabolism in muscular tissue normalized by day 30 after restoration of blood flow. Circulatory hypoxia for 7 and 9 h led to failure of the compensatory-adaptive mechanisms of homeostasis of the muscular tissue and required performance of regional detoxication therapy before restoration of circulation in the extremity.
在对狗的实验中，作者模拟了肢体急性缺血，并研究了血清中乳酸脱氢酶的活性。在循环缺血2小时和4小时的情况下，肌肉组织中的代谢在恢复血流后第30天恢复正常。循环性缺氧7小时和9小时导致肌肉组织内稳态的代偿 - 适应机制失效，并且在恢复肢体循环之前需要进行局部解毒治疗。
