Micklefield G H, Schött D, Kuntz H D, May B, Ulmer W T
Abteilung für Gastroenterologie und Hepatologie Medizinischen Universitätsklinik Bergmannsheil, Bochum.
Klin Wochenschr. 1989 Aug 17;67(16):833-8. doi: 10.1007/BF01725200.
Patients suffering from chronic obstructive airway disease often have arterial hypoxemia, which is more or less severe. If hypoxemia deteriorates the function of the liver is still unknown. The aim of this study was to determine, if a mostly oxygen dependent process of liver metabolism (galactose elimination capacity) is disturbed and if it can be increased by oxygen insufflation. Under the same conditions an oxygen independent process (indocyaninegreen clearance) should not be influenced. Our results show, that galactose elimination capacity under room air was pathologic and can be increased significantly by oxygen breathing. No change of indocyaninegreen clearance was seen under the same conditions. After termination of oxygen therapy the galactose elimination capacity was as bad as before oxygen breathing. Dysfunctions of the liver, which are caused by hypoxemia, can be positively influenced by oxygen, but only for the duration of oxygen insufflation.
患有慢性阻塞性气道疾病的患者常常存在程度不一的动脉血氧不足。低氧血症是否会使肝功能恶化尚不清楚。本研究的目的是确定肝脏代谢中主要依赖氧气的过程（半乳糖清除能力）是否受到干扰，以及通过吸氧是否可以提高该能力。在相同条件下，不依赖氧气的过程（吲哚菁绿清除率）不应受到影响。我们的结果表明，在室内空气中时半乳糖清除能力呈病理性，通过吸氧可显著提高。在相同条件下，吲哚菁绿清除率未见变化。氧疗结束后，半乳糖清除能力与吸氧前一样差。由低氧血症引起的肝功能障碍可通过吸氧得到积极改善，但仅在吸氧期间有效。
