Delgado J R, Carrión J R, Pérez-Manga G, Mayayo M, Ramos M
Med Clin (Barc). 1989 Jul 1;93(5):178-80.
We report a two and a half years old girl diagnosed in 1972 of lymphoblastic leukemia-lymphoma with pleural, mediastinal and bone marrow involvement. Clinical remission developed with chemotherapy (induction and maintenance). This situation persisted until June 1986 (14 years after the diagnosis and 11 years after cessation of any therapy), when mediastinal mass, pleural effusion and bilateral renal infiltration developed again, and also peripheral lymphadenopathy; bone marrow involvement is now absent. This case is considered as an exceptionally late relapse. Other possibilities are discussed, while the difficulty to define "cure" in these patients is emphasized.
我们报告了一名1972年被诊断为淋巴细胞白血病-淋巴瘤的两岁半女孩，伴有胸膜、纵隔和骨髓受累。化疗（诱导和维持）后出现临床缓解。这种情况一直持续到1986年6月（诊断后14年，停止任何治疗后11年），此时纵隔肿块、胸腔积液和双侧肾脏浸润再次出现，同时还有外周淋巴结病；目前骨髓未受累。该病例被认为是异常晚期复发。文中讨论了其他可能性，同时强调了在这些患者中定义“治愈”的困难。
