Rootare H M, Craig R G
J Oral Rehabil. 1978 Jul;5(3):293-307. doi: 10.1111/j.1365-2842.1978.tb01247.x.
Synthetic HAP made in the laboratory as 'synthetic bone' may be a possible replacement or repair material, since the mineral phase of dental hard tissue and bone is essentially hydroxyapatite in form. Hydroxyapatite or modified compositions of HAP appear to offer possibilities as a substitute for the original material provided by nature. A high surface area (70.4 m2/g) commercially available hydroxyapatite (HAP) of poor crystallinity was converted to a highly crystalline HAP through sintering at 1200 degrees C in an atmosphere of steam and nitrogen. Compacts were made of the powdered HAP from 500 to 25,000 psi and sintered under the same conditions. The changes in the resulting pore volumes, pore sizes, pore size distributions, densities, and surface areas of the sintered compacts were determined by mercury porosimetry. A 20-fold reduction in open pore volume for sintered compacts was observed. For compacts made at pressures above 5000 psi, the reduction in open pore volume was compensated for by the formation of closed pore volume. The sintering mechanism was attributed mainly to neck formation, growth between particles, diffusion, and plastic deformation.
在实验室中制成的作为“合成骨”的合成羟基磷灰石（HAP）可能是一种潜在的替代或修复材料，因为牙齿硬组织和骨骼的矿物相本质上是羟基磷灰石形式。羟基磷灰石或改性的HAP组合物似乎有可能替代天然提供的原始材料。通过在蒸汽和氮气气氛中于1200℃烧结，将一种市售的低结晶度高表面积（70.4 m2/g）羟基磷灰石（HAP）转化为高结晶度的HAP。用500至25,000 psi的HAP粉末制成坯块，并在相同条件下烧结。通过压汞法测定烧结坯块的孔隙体积、孔径、孔径分布、密度和表面积的变化。观察到烧结坯块的开孔体积减少了20倍。对于在5000 psi以上压力下制成的坯块，开孔体积的减少通过闭孔体积的形成得到补偿。烧结机制主要归因于颈部形成、颗粒间生长、扩散和塑性变形。
