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人源微小RNA-376c-3p对胃癌生长具有双向调控作用。 （你提供的原文似乎不完整，此译文是根据推测补充完整意思后的结果。）

hsa-miR-376c-3p Regulates Gastric Tumor Growth Both and .

作者信息

Tu Lin, Zhao Enhao, Zhao Wenyi, Zhang Zizhen, Tang Defeng, Zhang Yeqian, Wang Chaojie, Zhuang Chun, Cao Hui

机构信息

Department of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

出版信息

Biomed Res Int. 2016;2016:9604257. doi: 10.1155/2016/9604257. Epub 2016 Nov 14.

DOI:10.1155/2016/9604257
PMID:27965982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5124681/
Abstract

. In recent studies, aberrant expression of various microRNAs (miRNAs) is reported to be associated with gastric cancer metastasis. . Overexpression construct and inhibitor of hsa-miR-376c-3p were expressed in human gastric adenocarcinoma cell line SGC-7901. The expression level of tumor related genes was detected by qPCR, western blot, and immunostaining. Cell apoptosis was determined by flow cytometry. Xenograft of SGC-7901 cells was used to elucidate the function of hsa-miR-376c-3p in gastric tumor growth . . Expression of hsa-miR-376c-3p was detected in SGC-7901 cells. Downregulation of hsa-miR-376c-3p increased the expression level of BCL-2 and decreased the expression of smad4 and BAD. On the contrary, overexpression of hsa-miR-376c-3p increased the expression of BAD and smad4, while it led to the decreasing expression level of BCL-2. Overexpression of hsa-miR-376c-3p also promoted cell apoptosis and inhibited gastric tumor growth . Furthermore, the expression of BCL-2 was higher and expression of smad4 and BAD was lower in tumor tissue than the tissue adjacent to tumor from gastric cancer patients. . This study demonstrated that hsa-miR-376c-3p plays an important role in the inhibition of gastric tumor growth and tumor related gene expression both and .

摘要

在最近的研究中，据报道各种微小RNA（miRNA）的异常表达与胃癌转移有关。在人胃腺癌细胞系SGC-7901中表达了hsa-miR-376c-3p的过表达构建体和抑制剂。通过qPCR、蛋白质印迹和免疫染色检测肿瘤相关基因的表达水平。通过流式细胞术测定细胞凋亡。利用SGC-7901细胞的异种移植来阐明hsa-miR-376c-3p在胃肿瘤生长中的功能。在SGC-7901细胞中检测到hsa-miR-376c-3p的表达。hsa-miR-376c-3p的下调增加了BCL-2的表达水平，降低了smad4和BAD的表达。相反，hsa-miR-376c-3p的过表达增加了BAD和smad4的表达，同时导致BCL-2的表达水平降低。hsa-miR-376c-3p的过表达还促进了细胞凋亡并抑制了胃肿瘤生长。此外，在胃癌患者的肿瘤组织中，BCL-2的表达高于肿瘤旁组织，而smad4和BAD的表达低于肿瘤旁组织。这项研究表明，hsa-miR-376c-3p在抑制胃肿瘤生长和肿瘤相关基因表达方面均发挥着重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477a/5124681/c5021a28dbd9/BMRI2016-9604257.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477a/5124681/0fdfd57a3b27/BMRI2016-9604257.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477a/5124681/2b102dc7a0d3/BMRI2016-9604257.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477a/5124681/70017a9f1039/BMRI2016-9604257.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477a/5124681/890ffe796b94/BMRI2016-9604257.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477a/5124681/9e2cece6efa8/BMRI2016-9604257.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477a/5124681/c5021a28dbd9/BMRI2016-9604257.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477a/5124681/0fdfd57a3b27/BMRI2016-9604257.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477a/5124681/2b102dc7a0d3/BMRI2016-9604257.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477a/5124681/70017a9f1039/BMRI2016-9604257.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477a/5124681/890ffe796b94/BMRI2016-9604257.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477a/5124681/9e2cece6efa8/BMRI2016-9604257.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/477a/5124681/c5021a28dbd9/BMRI2016-9604257.006.jpg

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