Rikans L E, Snowden C D
Department of Pharmacology, University of Oklahoma College of Medicine, Oklahoma City 73190.
Life Sci. 1989;45(15):1373-9. doi: 10.1016/0024-3205(89)90024-6.
Female Fischer 344 rats, aged 4, 14, and 25 months, received 4.0 g/kg of ethanol by intraperitoneal (i.p.) injection. Blood alcohol concentrations 2.5, 6 and 16 hr after ethanol injection were similar in the three age groups. Hepatic glutathione (GSH) levels were diminished 6 hr after ethanol injection, and there were no age-dependent differences in the depleted levels (3.2 +/- 0.1, 3.5 +/- 0.2, and 3.0 +/- 0.5 micrograms GSH/g liver). However, GSH contents in livers of young-adult rats approached control levels after 16 hr, whereas they remained depressed in older rats. Serum levels of hepatic enzymes were significantly elevated 6 hr after ethanol administration. The increases were greater in middle-aged and old rats than in young-adult rats. The results suggest that middle-aged and old rats are more susceptible than young rats to the acute toxicity of ethanol.
4个月、14个月和25个月大的雌性Fischer 344大鼠通过腹腔注射给予4.0 g/kg乙醇。三个年龄组在乙醇注射后2.5小时、6小时和16小时的血醇浓度相似。乙醇注射6小时后肝脏谷胱甘肽（GSH）水平降低，且消耗水平不存在年龄依赖性差异（3.2±0.1、3.5±0.2和3.0±0.5微克GSH/克肝脏）。然而，年轻成年大鼠肝脏中的GSH含量在16小时后接近对照水平，而老年大鼠的GSH含量仍处于较低水平。乙醇给药6小时后，血清肝酶水平显著升高。中年和老年大鼠的升高幅度大于年轻成年大鼠。结果表明，中年和老年大鼠比年轻大鼠对乙醇的急性毒性更敏感。
