Ceccarelli M, Nutini P, Calevro L, Angelotti L, Lupetti L, Bartelloni M
Minerva Pediatr. 1989 May;41(5):247-51.
A deficiency of exogenous and endogenous carnitine is present in those pathologies in which the most important clinical sign is represented by weakness and steatosis. We have studied the serum levels of carnitine in 14 children with hepatic disease (8 with acute HAV hepatitis, 2 with acute HBV hepatitis, 2 with toxic hepatitis, 2 with chronic hepatitis). In patients with acute, infective and toxic hepatitis we have found levels of carnitine (25.71 +/- 2.14 nM/ml) below normal (50.87 +/- 1.46 nM/ml). In 5 cases we have performed two blood tests, at admittance to the hospital and at the end of the illness. The variability in carnitine levels in these two blood exams shows a clear correlation with clinical improvement, decrease in aminotransferase and increase in serum carnitine. In chronic hepatitis we have found normal levels of carnitine. Probably it is correlated with the absence of steatosis seen at hepatic biopsy.
在那些以虚弱和脂肪变性为最重要临床体征的病症中，存在外源性和内源性肉碱缺乏的情况。我们研究了14例肝病患儿（8例甲型肝炎病毒急性肝炎、2例乙型肝炎病毒急性肝炎、2例中毒性肝炎、2例慢性肝炎）的血清肉碱水平。在急性、感染性和中毒性肝炎患者中，我们发现肉碱水平（25.71±2.14 nM/ml）低于正常水平（50.87±1.46 nM/ml）。在5例患者中，我们在入院时和疾病末期进行了两次血液检测。这两次血液检查中肉碱水平的变化与临床改善、转氨酶降低及血清肉碱升高明显相关。在慢性肝炎患者中，我们发现肉碱水平正常。这可能与肝活检中未见脂肪变性有关。
