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由一个缺乏MyoD1结合位点的调控元件控制的肌肉特异性基因表达。

Muscle-specific gene expression controlled by a regulatory element lacking a MyoD1-binding site.

作者信息

Baldwin T J, Burden S J

机构信息

Biology Department, Massachusetts Institute of Technology, Cambridge 02139.

出版信息

Nature. 1989 Oct 26;341(6244):716-20. doi: 10.1038/341716a0.

DOI:10.1038/341716a0
PMID:2797207
Abstract

Muscle-specific expression of the gene encoding the delta subunit of the acetylcholine receptor is controlled by a 54-base-pair region that does not contain a binding site for MyoD1, a protein involved in activation of the myogenic program. A MyoD1-binding site is present in the proximal promoter region of the gene encoding the delta-subunit, but is neither sufficient nor necessary for muscle-specific expression in transfected muscle cells.

摘要

编码乙酰胆碱受体δ亚基的基因在肌肉中的特异性表达受一个54个碱基对区域的控制，该区域不包含MyoD1的结合位点，MyoD1是一种参与肌源性程序激活的蛋白质。在编码δ亚基的基因近端启动子区域存在一个MyoD1结合位点，但对于转染的肌肉细胞中的肌肉特异性表达而言，它既不充分也不必要。

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Nature. 1989 Oct 26;341(6244):716-20. doi: 10.1038/341716a0.
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