Zhao Ruilong, Liang Helena, Clarke Elizabeth, Jackson Christopher, Xue Meilang
Sutton Arthritis Research Laboratory, Kolling Institute of Medical Research, University of Sydney, NSW 2065, Australia.
Murray Maxwell Biomechanics Laboratory, Kolling Institute of Medical Research, University of Sydney, NSW 2065, Australia.
Int J Mol Sci. 2016 Dec 11;17(12):2085. doi: 10.3390/ijms17122085.
Non-healing chronic wounds present a major biological, psychological, social, and financial burden on both individual patients and the broader health system. Pathologically extensive inflammation plays a major role in the disruption of the normal healing cascade. The causes of chronic wounds (venous, arterial, pressure, and diabetic ulcers) can be examined through a juxtaposition of normal healing and the rogue inflammatory response created by the common components within chronic wounds (ageing, hypoxia, ischaemia-reperfusion injury, and bacterial colonisation). Wound bed care through debridement, dressings, and antibiotics currently form the basic mode of treatment. Despite recent setbacks, pharmaceutical adjuncts form an interesting area of research.
难愈合的慢性伤口给个体患者和更广泛的卫生系统带来了重大的生物学、心理、社会和经济负担。病理上广泛的炎症在正常愈合级联反应的破坏中起主要作用。慢性伤口（静脉性、动脉性、压迫性和糖尿病性溃疡）的病因可以通过对比正常愈合过程与慢性伤口中常见成分（衰老、缺氧、缺血再灌注损伤和细菌定植）引发的异常炎症反应来研究。目前，通过清创、敷料和抗生素进行伤口床护理构成了基本的治疗模式。尽管最近遇到了挫折，但药物辅助治疗仍是一个有趣的研究领域。
