Liao S Matthew
Bioethics. 2017 Jan;31(1):20-26. doi: 10.1111/bioe.12308.
Mitochondrial replacement techniques (MRTs), known in the popular media as 'three-parent' or 'three-person' IVFs, have the potential to enable women with mitochondrial diseases to have children who are genetically related to them but without such diseases. In the debate regarding whether MRTs should be made available, an issue that has garnered considerable attention is whether MRTs affect the characteristics of an existing individual or whether they result in the creation of a new individual, given that MRTs involve the genetic manipulation of the germline. In other words, do MRTs affect the qualitative identity or the numerical identity of the resulting child? For instance, a group of panelists on behalf of the UK Human Fertilisation and Embryology Authority (HFEA) has claimed that MRTs affect only the qualitative identity of the resulting child, while the Working Group of the Nuffield Council on Bioethics (NCOB) has argued that MRTs would create a numerically distinct individual. In this article, I shall argue that MRTs do create a new and numerically distinct individual. Since my explanation is different from the NCOB's explanation, I shall also offer reasons why my explanation is preferable to the NCOB's explanation.
线粒体替代技术(MRTs),在大众媒体中被称为“三亲”或“三人”体外受精,有可能使患有线粒体疾病的女性生育出与她们有基因关联但没有此类疾病的孩子。在关于是否应提供MRTs的辩论中,一个备受关注的问题是,鉴于MRTs涉及生殖系的基因操作,它是会影响现有个体的特征,还是会导致一个新个体的产生。换句话说,MRTs会影响所生孩子的质的同一性还是数的同一性?例如,代表英国人类受精与胚胎学管理局(HFEA)的一组专家声称,MRTs仅影响所生孩子的质的同一性,而纳菲尔德生物伦理委员会(NCOB)的工作组则认为,MRTs会创造出一个在数上不同的个体。在本文中,我将论证MRTs确实会创造出一个新的、在数上不同的个体。由于我的解释与NCOB的不同,我还将说明为何我的解释比NCOB的解释更可取。