Yamashita H, Toba T, Yasunaga A, Shibata S, Mori K, Shimada O
Department of Neurosurgery, Nagasaki University School of Medicine.
No Shinkei Geka. 1989 Sep;17(9):887-91.
The authors reported a rare case of primary malignant melanoma in the central nervous system and discussed the findings of MRI. A 60-year-old male was admitted for examinations to discover the cause of his generalized tonic convulsions. On admission, he had neither neurological deficits, nor were there any abnormalities revealed during physical examination. Ct scan disclosed a slightly high-density mass with perifocal edema in the right parietal cortex which enhanced markedly after injection of contrast material. This lesion was hypointense on T1 weighted image of MRI (GE: 1.5 Tesla) and a hyperintense band was observed on the surface of the tumor. On T2 weighted image, the tumor showed iso-hypointensity surrounded by an increased signal area compatible with edema. On August 31, 1988, a gross total removal of the tumor was performed. Microscopically, it was identified as a malignant melanoma. No melanoma was found in other parts of the body during careful examinations, especially in dermatologic and ophthalmologic examinations. Characteristic findings of the hyperintense band on T1 weighted image coincided well with the pathological findings of excessive melanin deposition on the surface of the tumor, and which resulted from the paramagnetic free-radicals in the melanin. MR image may be useful for differentiation of intracranial malignant melanomas from other mass lesions.
作者报告了一例罕见的中枢神经系统原发性恶性黑色素瘤病例,并讨论了MRI检查结果。一名60岁男性因全身性强直惊厥病因入院检查。入院时,他既无神经功能缺损,体格检查也未发现任何异常。CT扫描显示右侧顶叶皮质有一稍高密度肿块,周围有灶周水肿,注射造影剂后明显强化。该病变在MRI(GE:1.5特斯拉)的T1加权像上呈低信号,肿瘤表面可见一条高信号带。在T2加权像上,肿瘤呈等低信号,周围为信号增高区,符合水肿表现。1988年8月31日,肿瘤被完整切除。显微镜下,其被确诊为恶性黑色素瘤。在仔细检查过程中,尤其是皮肤科和眼科检查,未在身体其他部位发现黑色素瘤。T1加权像上高信号带的特征性表现与肿瘤表面黑色素过度沉积的病理结果高度相符,这是由黑色素中的顺磁性自由基导致的。MR图像可能有助于颅内恶性黑色素瘤与其他肿块性病变的鉴别。