对于所有因任何原因导致不孕的患者来说，滑行（coasting）都有价值吗？
Is Coasting Valuable in All Patients with Any Cause of Infertility?
作者信息
Madani Tahereh, Jahangiri Nadia, Eftekhari-Yazdi Poopak, Ashrafi Mahnaz, Akhoond Mohammadreza
机构信息
Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
出版信息
Oman Med J. 2016 Nov;31(6):404-408. doi: 10.5001/omj.2016.82.
OBJECTIVES
This study aimed to assess the influence of coasting duration on the number and quality of oocytes and fertilization rate in male factor infertile women and those with polycystic ovary syndrome (PCOS).
METHODS
In this prospective observational follow-up study, 114 patients undergoing coasting (53 women with male factor infertility and 61 women with PCOS) were evaluated at the Royan Institute Research Center, Iran, between 2010 and 2012.
RESULTS
The results were analyzed according to the coasting periods of 1-4 days. In normal females, the number of oocytes retrieved was significantly reduced after the second day ( = 0.004). In addition, a statistically significant drop was observed in the number of metaphase II oocytes and fertilization rate after the third day ( = 0.006 and = 0.006, respectively). No significant differences were observed in the number and quality of oocytes retrieved and fertilization rate with regard to coasting days in PCOS patients.
CONCLUSION
Coasting with duration of more than three days should be performed with caution in normal females who are at risk of developing ovarian hyperstimulation syndrome.
目的
本研究旨在评估在男性因素不孕女性及多囊卵巢综合征（PCOS）患者中，延缓刺激时间对卵母细胞数量与质量以及受精率的影响。
方法
在这项前瞻性观察性随访研究中，2010年至2012年间，于伊朗罗扬研究所研究中心对114例接受延缓刺激的患者（53例男性因素不孕女性和61例PCOS女性）进行了评估。
结果
根据1 - 4天的延缓刺激期对结果进行分析。在正常女性中，第二天后回收的卵母细胞数量显著减少（P = 0.004）。此外，第三天后观察到中期II卵母细胞数量和受精率有统计学意义的下降（分别为P = 0.006和P = 0.006606）。PCOS患者回收的卵母细胞数量和质量以及受精率在延缓刺激天数方面未观察到显著差异。
结论
对于有发生卵巢过度刺激综合征风险的正常女性，延缓刺激超过三天应谨慎进行。
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