Leyva-Ramos S, Hernández-López H
Hiram Hernández López. Unidad Académica de Ciencias Químicas. Universidad Autónoma de Zacatecas. Carretera Zacatecas-Guadalajara km 6, Ejido la Escondida s/n, Edificio 6. Zacatecas, Zac., 98160, México.
Rev Esp Quimioter. 2017 Feb;30(1):1-8. Epub 2016 Dec 15.
Fluoroquinolones are a class of well-established chemotherapeutic agents with a potent biological activity being the structure of 4-quinolone-3-carboxilic acids privileged because it contains different sites for functionalization allowing expand its use in clinical practice for their antifungal, antiviral and anticancer activities. Quinolones structural changes have resulted in a first, second, third and fourth generation of drugs so it is advisable to continue modifying existing structures in new ways to generate compounds with desirable biological and pharmacological properties.
氟喹诺酮类是一类成熟的化疗药物，具有强大的生物活性，其4-喹诺酮-3-羧酸结构具有优势，因为它含有不同的官能团化位点，这使得它能够因其抗真菌、抗病毒和抗癌活性而在临床实践中得到更广泛的应用。喹诺酮类药物的结构变化导致了第一代、第二代、第三代和第四代药物的出现，因此，建议继续以新的方式修饰现有结构，以生成具有理想生物学和药理学特性的化合物。
