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[核糖核酸水解产物离子导入疗法对中毒性视网膜病变的疗效]

[The therapeutic efficacy of phonophoresis of ribonucleic acid hydrolysate in toxic retinal lesions].

作者信息

Plevinskis V P, Skrinnik A S, Fuks B B, Bormusova E A, Konovalova N V

出版信息

Oftalmol Zh. 1989(3):181-4.

PMID:2797684
Abstract

Experiments on 82 rabbits (162 eyes) have shown that RNA hydrolysate phonophoresis possesses a pronounced protective action by stimulating a rapid cupping of metabolic disturbances and a restoration of the chemical state of cellular elements of the retina in a relatively remote terms after the introducing of a monobromoacetate inhibitor (within first 3 days). Experimental therapy beginning 10 days after the introducing of monobromoacetate, i. e. in the period when, besides metabolic disturbances histomorphologic changes were also seen, considerably stimulated activation of compensatory-inflammatory processes. The investigations carried out allow to recommend RNA hydrolysate phonophoresis for clinical examination in dystrophic diseases of the retina.

摘要

对82只兔子(162只眼睛)进行的实验表明,RNA水解物离子导入通过刺激代谢紊乱的快速消除以及在引入一溴乙酸抑制剂后(前3天内)相对较长时间内恢复视网膜细胞成分的化学状态,具有显著的保护作用。在引入一溴乙酸10天后开始实验性治疗,即在除了代谢紊乱还出现组织形态学变化的时期,大大刺激了代偿性炎症过程的激活。所进行的研究允许推荐RNA水解物离子导入用于视网膜营养不良性疾病的临床检查。

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