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[产前给予皮质酮后雄性大鼠生殖系统的产后发育]

[The postnatal development of the genital system in male rats following the prenatal administration of corticosterone].

作者信息

Shishkina G T, Bykova T S

出版信息

Ontogenez. 1989 Jul-Aug;20(4):431-4.

PMID:2797707
Abstract

Corticosterone administration to pregnant Wistar rats on days 16 and 18 of pregnancy leads to changes in genital system of male offspring during postnatal ontogenesis: reduction of ano-genital distance in two days old rats, increase of preputial glands' weight in 35 and 70 day old embryos, changes in nature of puberal increase in testosterone blood level from day 35 to day 70 of life. The obtained data suggest that the increase in the corticosteroid level in blood of pregnant females owing to any stress factor can affect the postnatal development of genital system of male offspring.

摘要

在妊娠第16天和第18天给怀孕的Wistar大鼠注射皮质酮,会导致雄性后代在出生后的个体发育过程中生殖系统发生变化:两天大的大鼠肛门与生殖器间距离缩短,35日龄和70日龄幼鼠的包皮腺重量增加,出生后第35天至第70天青春期睾酮血水平升高的性质发生改变。所获数据表明,由于任何应激因素导致怀孕雌性大鼠血液中皮质类固醇水平升高,可能会影响雄性后代生殖系统的出生后发育。

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