Copenhagen Affective Disorder Research Centre, Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Copenhagen Affective Disorder Research Centre, Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Neurosci Biobehav Rev. 2017 Feb;73:1-22. doi: 10.1016/j.neubiorev.2016.12.011. Epub 2016 Dec 12.
The phenomenology and underlying pathophysiology of bipolar disorder (BD) are heterogeneous. The identification of putative endophenotypes for BD can aid in the investigation of unique patho-etiological pathways, which may lead to the development of personalised preventative and therapeutic approaches for this multi-faceted disorder. We included original studies involving unaffected first-degree relatives of BD patients (URs) and a healthy control (HC) comparison group with no first-degree family history of mental disorders, investigating: 'cold' and 'hot' cognition and functional and structural neuroimaging. Seventy-seven cross-sectional studies met the inclusion criteria. The present review revealed that URs in comparison with HCs showed: (i) widespread deficits in verbal memory, sustained attention, and executive function; (ii) abnormalities in the reactivity to and regulation of emotional information along with aberrant reward processing, and heightened attentional interference by emotional stimuli; and (iii) less consistency in the findings regarding structural and resting state neuroimaging, and electrophysiological measures.
双相障碍（BD）的现象学和潜在病理生理学具有异质性。BD 的假定内表型的识别可以帮助研究独特的病理发病途径，这可能为这种多方面的疾病开发个性化的预防和治疗方法。我们纳入了涉及 BD 患者无患病一级亲属（URs）和无精神障碍家族史的健康对照组（HC）的原始研究，研究内容包括：“冷”和“热”认知以及功能和结构神经影像学。有 77 项横断面研究符合纳入标准。本综述显示，与 HC 相比，URs 表现出：（i）言语记忆、持续注意力和执行功能广泛受损；（ii）对情绪信息的反应和调节异常，以及异常的奖励处理，情绪刺激引起的注意力干扰增加；（iii）关于结构和静息状态神经影像学以及电生理测量的发现一致性较低。
