Carr Tara F, Bleecker Eugene
Asthma and Airway Disease Research Center, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724-5030 USA.
Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC USA.
World Allergy Organ J. 2016 Nov 29;9(1):41. doi: 10.1186/s40413-016-0131-2. eCollection 2016.
Asthma is a common, chronic inflammatory airways disease characterized by a clinical syndrome of bronchial hyperresponsiveness, inflammation, and reversible airflow obstruction. Individuals with asthma can vary widely in clinical presentation, severity, and pathobiology. The incident factors, pathogenesis, prognosis, and treatment of asthma remain incompletely understood. Utilizing measurable characteristics of asthmatic patients, including demographic, physiologic, and biologic markers, can however identify meaningful phenotypic categories in asthma. Identification of these phenotypes may help improve precision therapeutics targeted toward an individual's' disease, and may identify strategies for preventing progression of disease severity.
哮喘是一种常见的慢性炎症性气道疾病，其特征为支气管高反应性、炎症和可逆性气流受限的临床综合征。哮喘患者的临床表现、严重程度和病理生物学存在很大差异。哮喘的发病因素、发病机制、预后和治疗仍未完全明确。然而，利用哮喘患者的可测量特征，包括人口统计学、生理学和生物学标志物，可以识别哮喘中有意义的表型类别。识别这些表型可能有助于提高针对个体疾病的精准治疗，并可能确定预防疾病严重程度进展的策略。
