裸鼠在硼-10-双对羟苯基丙氨酸实验性中子俘获治疗中的应用。
Use of nude mice in experimental neutron capture therapy with 10B-BPA.
作者信息
Tamaoki N, Ueda M, Tamauchi S, Yamamoto K, Mishima Y
机构信息
Department of Pathology, School of Medicine, Tokai University, Kanagawa-ken, Japan.
出版信息
Pigment Cell Res. 1989 Jul-Aug;2(4):343-4. doi: 10.1111/j.1600-0749.1989.tb00216.x.
Abstract
Mouse B16 melanoma allografts in nude mice were successfully treated by thermal neutron irradiation after IP injection of 10B-paraboronophenylalanine hydrochloride. The tumor growth was significantly suppressed for 4 weeks after irradiation, compared with animals given neutron irradiation alone. Tumor-bearing nude mice were shown to be useful for evaluating the treatment for melanoma.
摘要
在裸鼠体内注射盐酸10B-硼苯丙氨酸后，通过热中子辐照成功治疗了裸鼠体内的小鼠B16黑色素瘤同种异体移植物。与仅接受中子辐照的动物相比，辐照后4周肿瘤生长受到显著抑制。结果表明，荷瘤裸鼠可用于评估黑色素瘤的治疗效果。
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