Fukuda H, Kobayashi T, Hiratsuka J, Karashima H, Honda C, Yamamura K, Ichihashi M, Kanda K, Mishima Y
Division of Clinical Research, National Institute of Radiological Sciences, Chiba, Japan.
Pigment Cell Res. 1989 Jul-Aug;2(4):365-9. doi: 10.1111/j.1600-0749.1989.tb00222.x.
A patient with malignant melanoma was treated by thermal neutron capture therapy using 10B-paraboronophenylalanine. The compound was injected subcutaneously into ten locations in the tumor-surrounding skin, and the patient was then irradiated with thermal neutrons from the Musashi Reactor at reactor power of 100 KW and neutron flux of 1.2 X 10(9) n/cm2/s. Total absorbed dose to the skin was 11.7-12.5 Gy in the radiation field. The dose equivalents of these doses were estimated as 21.5 and 24.4 Sv, respectively. Early skin reaction after irradiation was checked from day 1 to day 60. The maximum and mean skin scores were 2.0 and 1.5, respectively, and the therapy was safely completed as far as skin reaction was concerned. Some factors influencing the absorbed dose and dose equivalent to the skin are discussed.
一名恶性黑色素瘤患者接受了使用10B-对硼苯丙氨酸的热中子俘获疗法。将该化合物皮下注射到肿瘤周围皮肤的十个部位，然后患者接受来自武藏反应堆的热中子照射，反应堆功率为100千瓦，中子通量为1.2×10(9) n/cm2/s。辐射野中皮肤的总吸收剂量为11.7-12.5 Gy。这些剂量的剂量当量估计分别为21.5和24.4 Sv。在照射后的第1天至第60天检查早期皮肤反应。最大和平均皮肤评分分别为2.0和1.5，就皮肤反应而言，治疗安全完成。讨论了一些影响皮肤吸收剂量和剂量当量的因素。
