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Brentuximab vedotin and bendamustine produce high complete response rates in patients with chemotherapy refractory Hodgkin lymphoma.

作者信息

Kalac Matko, Lue Jennifer K, Lichtenstein Emily, Turenne Ithamar, Rojas Celeste, Amengual Jennifer E, Sawas Ahmed, Deng Changchun, Mapara Markus Y, Connors Joseph M, Kuruvilla John, O'Connor Owen A

机构信息

Center for Lymphoid Malignancies, Columbia University Medical Center, New York, NY, USA.

Department of Hematology and Oncology, Columbia University Medical Center, New York, NY, USA.

出版信息

Br J Haematol. 2018 Mar;180(5):757-760. doi: 10.1111/bjh.14449. Epub 2016 Dec 16.

DOI:10.1111/bjh.14449
PMID:27984643
Abstract
摘要

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Brentuximab vedotin and bendamustine produce high complete response rates in patients with chemotherapy refractory Hodgkin lymphoma.在化疗难治性霍奇金淋巴瘤患者中,维布妥昔单抗和苯达莫司汀产生了高完全缓解率。
Br J Haematol. 2018 Mar;180(5):757-760. doi: 10.1111/bjh.14449. Epub 2016 Dec 16.
2
Bendamustine can be a bridge to allogeneic transplantation in relapsed Hodgkin lymphoma refractory to brentuximab vedotin.苯达莫司汀可作为复发的、对本妥昔单抗难治的霍奇金淋巴瘤进行异基因移植的桥梁。
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Safety and efficacy of single-agent bendamustine after failure of brentuximab vedotin in patients with relapsed or refractory hodgkin's lymphoma: experience with 27 patients.复发或难治性霍奇金淋巴瘤患者接受本妥昔单抗治疗失败后单药苯达莫司汀的安全性和有效性:27例患者的经验
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The European Medicines Agency Review of Brentuximab Vedotin (Adcetris) for the Treatment of Adult Patients With Relapsed or Refractory CD30+ Hodgkin Lymphoma or Systemic Anaplastic Large Cell Lymphoma: Summary of the Scientific Assessment of the Committee for Medicinal Products for Human Use.欧洲药品管理局对用于治疗复发或难治性CD30+霍奇金淋巴瘤或系统性间变性大细胞淋巴瘤成年患者的本妥昔单抗(安适利)的审评:人用药品委员会科学评估总结
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Bendamustine as a bridge to allogeneic transplant in relapsed/refractory Hodgkin lymphoma patients who failed salvage brentuximab vedotin postautologous peripheral blood stem cell transplantation.苯达莫司汀作为复发/难治性霍奇金淋巴瘤患者异基因移植的桥梁,这些患者在自体外周血干细胞移植后接受挽救性本妥昔单抗治疗失败。
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Treatment with brentuximab vedotin plus bendamustine in unselected patients with CD30-positive aggressive lymphomas.在未经选择的 CD30 阳性侵袭性淋巴瘤患者中,采用 Brentuximab Vedotin 联合苯达莫司汀治疗。
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Results of a Multicenter Phase II Trial of Brentuximab Vedotin as Second-Line Therapy before Autologous Transplantation in Relapsed/Refractory Hodgkin Lymphoma.复发/难治性霍奇金淋巴瘤自体移植前,以本妥昔单抗作为二线治疗的多中心II期试验结果。
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引用本文的文献

1
Bendamustine supercharge plus brentuximab vedotin as early salvage therapy following failure to obtain complete metabolic remission after two cycles of adriamycin-bleomycin-vinblastine-dacarbazine for classic Hodgkin lymphoma in patients aged ≤ 60 years: Long-term efficacy results of a retrospective multicentre study.对于年龄≤60岁的经典型霍奇金淋巴瘤患者,在接受两个周期的阿霉素-博来霉素-长春花碱-达卡巴嗪治疗后未获得完全代谢缓解时,苯达莫司汀强化联合 Brentuximab vedotin 作为早期挽救治疗:一项回顾性多中心研究的长期疗效结果。
Br J Haematol. 2025 May;206(5):1502-1507. doi: 10.1111/bjh.20053. Epub 2025 Apr 2.
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Filling the Gap: The Immune Therapeutic Armamentarium for Relapsed/Refractory Hodgkin Lymphoma.填补空白:复发/难治性霍奇金淋巴瘤的免疫治疗武器库
J Clin Med. 2022 Nov 6;11(21):6574. doi: 10.3390/jcm11216574.
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Novel Salvage Therapy Options for Initial Treatment of Relapsed/Refractory Classical Hodgkin's Lymphoma: So Many Options, How to Choose?复发/难治性经典型霍奇金淋巴瘤初始治疗的新型挽救治疗方案:选择众多,如何抉择?
Cancers (Basel). 2022 Jul 20;14(14):3526. doi: 10.3390/cancers14143526.
4
Salvage Therapy for Hodgkin's Lymphoma: A Review of Current Regimens and Outcomes.霍奇金淋巴瘤的挽救治疗:当前治疗方案及结果综述
J Blood Med. 2020 Oct 27;11:389-403. doi: 10.2147/JBM.S250581. eCollection 2020.
5
Brentuximab vedotin followed by bendamustine supercharge for refractory or relapsed Hodgkin lymphoma.Brentuximab vedotin 序贯泊马度胺超剂量治疗难治或复发霍奇金淋巴瘤。
Blood Adv. 2019 May 14;3(9):1546-1552. doi: 10.1182/bloodadvances.2019000123.
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