Ghosh T K, Copeland R L, Gear J C, Pradhan S N
Department of Pharmacology, Howard University College of Medicine, Washington, DC 20059.
Pharmacol Biochem Behav. 1989 Apr;32(4):987-92. doi: 10.1016/0091-3057(89)90071-3.
Effects of toluene on the electroencephalogram (EEG) and its power spectra were measured during a 2-hr exposure in a dynamic inhalational chamber in rats. Rats were exposed to one of six graded concentrations (110.6, 162.5, 432, 676, 1558, 2730 ppm) of toluene on different days. It was found that the duration of waking (W) was increased with a decrease in duration of rapid eye movement (REM) sleep even at 110.6 ppm. Duration of nonrapid eye movement (NREM) sleep was decreased with an increase of W and a decrease of REM sleep at 162.5 ppm. Dose-related effects were noted in higher concentrations. The power of delta frequency band was increased with a decrease of theta frequency band power at hr 1 of exposure to 676 ppm during REM sleep recorded from the visual cortex. The power of theta frequency band was also decreased at hr 2 of exposure at 432 ppm. During W and NREM sleep power spectra were not changed significantly. Results indicate that the changes of EEG are a sensitive measure of the effects of toluene on the central nervous system (CNS).
在大鼠的动态吸入舱中进行2小时暴露期间，测量了甲苯对脑电图（EEG）及其功率谱的影响。在不同的日子里，将大鼠暴露于六种分级浓度（110.6、162.5、432、676、1558、2730 ppm）的甲苯中的一种。结果发现，即使在110.6 ppm时，清醒（W）时间也会增加，快速眼动（REM）睡眠的时间会减少。在162.5 ppm时，非快速眼动（NREM）睡眠的时间随着W的增加和REM睡眠的减少而减少。在更高浓度下观察到剂量相关效应。从视觉皮层记录的REM睡眠期间，在暴露于676 ppm的第1小时，δ频段的功率增加，而θ频段的功率降低。在暴露于432 ppm的第2小时，θ频段的功率也降低。在W和NREM睡眠期间，功率谱没有明显变化。结果表明，EEG的变化是甲苯对中枢神经系统（CNS）影响的敏感指标。
