Kingma M L, Kingma J G
Quebec Heart Institute, Laval Hospital, Faculty of Medicine, Laval University, Ste-Foy, Que., Canada.
Pharmacology. 1989;39(2):129-36. doi: 10.1159/000138588.
The effects of the triazolobenzodiazepine anxiolytic, alprazolam, on the incidence of ischemia- and reperfusion-induced ventricular arrhythmias was studied in the isolated buffer-perfused rat heart. Administration of alprazolam before and after myocardial ischemia resulted in a dosage-dependent reduction in the incidence and duration of reperfusion-induced ventricular fibrillation and was significant at a concentration of 1 X 10(-3) mol/l alprazolam. This cardioprotective effect was not extended to ischemia-induced ventricular dysrhythmias. In conclusion, our findings provide evidence that benzodiazepine drugs are able to provide a cardioprotective effect in the experimental setting of myocardial ischemia followed by coronary reperfusion.
在离体缓冲液灌注的大鼠心脏中，研究了三唑并苯二氮䓬类抗焦虑药阿普唑仑对缺血及再灌注诱发的室性心律失常发生率的影响。在心肌缺血前后给予阿普唑仑，可使再灌注诱发的心室颤动的发生率和持续时间呈剂量依赖性降低，在阿普唑仑浓度为1×10⁻³mol/L时具有显著意义。这种心脏保护作用并未扩展至缺血诱发的室性心律失常。总之，我们的研究结果表明，在心肌缺血后冠状动脉再灌注的实验环境中，苯二氮䓬类药物能够发挥心脏保护作用。
