Yılmaz Zehra Vural, Türkmen Gülenay Gençosmanoğlu, Yılmaz Elif, Dağlar Korkut, Kırbaş Ayşe, Sanhal Cem, Yücel Aykan, Uygur Dilek
Department of Perinatology, Zekai Tahir Burak Women's Health Education and Training Hospital, Ankara, Turkey.
Department of Obstetrics and Gynaecology, Dr. Sami Ulus Women's and Children's Health Training and Research Hospital, Ankara, Turkey.
J Obstet Gynaecol Res. 2017 Mar;43(3):511-515. doi: 10.1111/jog.13237. Epub 2016 Dec 17.
Behçet's disease (BD) is a rare and multisystemic vasculitis disease. In this study, we investigated whether BD had any effect on the biochemical components of first and second trimester aneuploidy screening tests.
A case-control retrospective study was conducted with 32 pregnant women with BD and 60 healthy pregnant women as controls. All pregnant womens' first trimester maternal serum pregnancy-associated plasma protein-A, free β-human chorionic gonadotropin and second trimester serum alpha-fetoprotein, unconjugated estriol and total human chorionic gonadotropin levels were examined from medical records. First and second serum screening markers were compared between pregnancies with BD and without.
There was no difference in age, body mass index and obstetric history between the groups. No significant difference was observed between the groups in terms of first and second trimester serum screening test results in the absence of aneuploidy or neural tube defect. Gestational age at birth, birth weight and neonatal intensive care admission rate were also similar between the groups.
Both first and second serum screening tests for Down syndrome may be recommended to pregnant women with BD without the need to readjust these markers. Pregnancy with BD was not associated with adverse perinatal outcome with respect to gestational age at birth or birth weight.
白塞病（BD）是一种罕见的多系统血管炎疾病。在本研究中，我们调查了BD是否对孕早期和孕中期非整倍体筛查试验的生化成分有任何影响。
进行了一项病例对照回顾性研究，以32名患有BD的孕妇和60名健康孕妇作为对照。从病历中检查了所有孕妇的孕早期母体血清妊娠相关血浆蛋白-A、游离β-人绒毛膜促性腺激素以及孕中期血清甲胎蛋白、非结合雌三醇和总人绒毛膜促性腺激素水平。比较了患有BD和未患BD的孕妇的孕早期和孕中期血清筛查标志物。
两组之间在年龄、体重指数和产科病史方面没有差异。在不存在非整倍体或神经管缺陷的情况下，两组在孕早期和孕中期血清筛查试验结果方面未观察到显著差异。两组之间的出生孕周、出生体重和新生儿重症监护入院率也相似。
对于患有BD的孕妇，可能建议进行孕早期和孕中期唐氏综合征血清筛查试验，而无需调整这些标志物。患有BD的孕妇在出生孕周或出生体重方面与不良围产期结局无关。
