Mueller Indra, Jansen-Park So-Hyun, Neidlin Michael, Steinseifer Ulrich, Abel Dirk, Autschbach Rüdiger, Rossaint Rolf, Schmitz-Rode Thomas, Sonntag Simon Johannes
Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, RWTH Aachen University, Pauwelsstr.20, 52074 Aachen.
Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, RWTH Aachen University, 52074 Aachen.
Biomed Tech (Berl). 2017 Apr 1;62(2):131-137. doi: 10.1515/bmt-2016-0104.
Right heart failure (RHF), e.g. due to pulmonary hypertension (PH), is a serious health issue with growing occurrence and high mortality rate. Limited efficacy of medication in advanced stages of the disease constitutes the need for mechanical circulatory support of the right ventricle (RV). An essential contribution to the process of developing right ventricular assist devices (RVADs) is the in vitro test bench, which simulates the hemodynamic behavior of the native circulatory system. To model healthy and diseased arterial-pulmonary hemodynamics in adults (mild and severe PH and RHF), a right heart mock circulation loop (MCL) was developed. Incorporating an anatomically shaped silicone RV and a silicone atrium, it not only enables investigations of hemodynamic values but also suction events or the handling of minimal invasive RVADs in an anatomical test environment. Ventricular pressure-volume loops of all simulated conditions as well as pressure and volume waveforms were recorded and compared to literature data. In an exemplary test, an RVAD was connected to the apex to further test the feasibility of studying such devices with the developed MCL. In conclusion, the hemodynamic behavior of the native system was well reproduced by the developed MCL, which is a useful basis for future RVAD tests.
右心衰竭（RHF），例如由肺动脉高压（PH）引起的，是一个日益严重的健康问题，发病率不断上升且死亡率很高。疾病晚期药物疗效有限，因此需要对右心室（RV）进行机械循环支持。体外试验台对开发右心室辅助装置（RVADs）的过程做出了重要贡献，它模拟了天然循环系统的血流动力学行为。为了模拟成人健康和患病的动脉-肺血流动力学（轻度和重度PH以及RHF），开发了一种右心模拟循环回路（MCL）。它包含一个解剖形状的硅胶右心室和一个硅胶心房，不仅能够研究血流动力学值，还能在解剖测试环境中研究抽吸事件或微创RVADs的操作。记录了所有模拟条件下的心室压力-容积环以及压力和容积波形，并与文献数据进行了比较。在一个示例性测试中，将一个RVAD连接到心尖，以进一步测试使用开发的MCL研究此类装置的可行性。总之，开发的MCL很好地再现了天然系统的血流动力学行为，这为未来的RVAD测试提供了有用的基础。
